Pair Name	Epigallocatechin gallate, Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Inhibition-->Autophagy
Gene Regulation	Down-regulation	Expression	ATG5	hsa9474
	Down-regulation	Expression	MAP1LC3B	hsa81631
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Up-regulation	Expression	SQSTM1	hsa8878
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
In Vivo Model	A549 cells were trypsinized, centrifuged, washed in PBS twice and injected s.c. (1×10⁶, 100 μL of PBS) into the left flanks of the 7–8-week-old mice (the animals were adapted to the lab environment for 7 days before experiments).
Result	EGCG overcomes Gef resistance by inhibiting autophagy and augmenting cell death through targeting ERK pathway in NSCLC. Gef and EGCG combination therapy may be an effective strategy to overcome acquired resistance in NSCLC.